1-β-D-Glucosylsphingadienine (d18:2 (4E,8E)) (Synonyms: Glucosylsphingadienine (d18:2 (4E,8E)), 1-β-D-Glucosylsphingadienine (plant), Glucosylsphingosine (plant)) |
| カタログ番号GC42050 |
1-β-D-グルコシルスフィンガジエニン (d18:2 (4E,8E)) は、グルコシルセレブロシドの脱アセチル化リゾ脂質誘導体であるグルコシルスフィンゴシンです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 114200-59-8
Sample solution is provided at 25 µL, 10mM.
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1-β-D-Glucosylsphingadienine is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucosylcerebrosides . They are formed when sphingosines undergo glucosidation by UDP-glucose. Glucosylsphingosines completely reduce neurite outgrowth and induce death of LA-N-2 cells at concentrations of 10 and 50 μM, respectively. They also decrease the activity of glucocerebrosidase in LA-N-2 cells in a dose-dependent manner. Glucosylsphingosine levels are elevated in patients with Gaucher's disease, both in the spleen (in types 1, 2, and 3) and brain (type 2 and 3); thus, glucosylsphingosine has been used as a key biomarker of the disease. This product contains 1-β-D-glucosylsphingadienine isolated from plants.
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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