(±)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (hydrobromide) (Synonyms: (±)-ADTN, 6,7-ADTN, 6,7-diOHATN, NSC 287353) |
| カタログ番号GC41657 |
(±)-2-アミノ-6,7-ジヒドロキシ-1,2,3,4-テトラヒドロナフタレン（6,7-ADTN）は、ドーパミン受容体作動薬であり、ラットのストリアタルおよび核偏差分画質においてEC50がそれぞれ3.5μMと0.65μMです。
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Cas No.: 13575-86-5
Sample solution is provided at 25 µL, 10mM.
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(±)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (6,7-ADTN) is a dopamine receptor agonist (EC50s = 3.5 and 0.65 μM in rat striatal and nucleus accumbens homogenates, respectively). 6,7-ADTN stimulates production of cAMP in rat striatal homogenates, a process that is reduced by 70% in the presence of the dopamine antagonist fluphenazine at a concentration of 1 μM. In vivo, 6,7-ADTN induces hyperlocomotion in rats when injected bilaterally at a dose of 100 nmol per side into the nucleus accumbens. It increases cAMP production and glycoprotein secretion in the albumen gland of H. duryi (snail). It also reduces sucrose feeding in R. maderae (cockroach) nymphs.
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