2'-Deoxy-5'-O-DMT-2'-fluorouridine |
| カタログ番号GC67627 |
2'-Deoxy-5'-O-DMT-2'-ヌクレオシド類似体であるフルオロウリジンは、5'-O-DMTr-5-FUDR 誘導体であり、強力な抗黄熱病 (YFV) 活性があります。
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Cas No.: 146954-74-7
Sample solution is provided at 25 µL, 10mM.
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2'-Deoxy-5'-O-DMT-2'-fluorouridine, a nucleoside analogue, is a 5'-O-DMTr-5-FUDR derivative with potent anti-yellow fever (YFV) activity[1].
2'-Deoxy-5'-O-DMT-2'-fluorouridine (compound 15h) has 100% inhibition against YFV at 20 mM. 2'-Deoxy-5'-O-DMT-2'-fluorouridine proves to be noncytotoxic at concen-trations up to 20 mM[1].
[1]. Christopher McGuigan, et al. Anti-flavivirus Activity of Different Tritylated Pyrimidine and Purine Nucleoside Analogues. ChemistryOpen. 2016 Jan 21;5(3):227-35.
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