4-Bromo-3-hydroxybenzoic acid |
| カタログ番号GC39473 |
4-ブロモ-3-ヒドロキシ安息香酸は、ブロクレシンの代謝産物であり、ラット胎児およびラット胃 HDC の IC50 が 1 mM のヒスチジン脱炭酸酵素 (HDC) 阻害剤です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 14348-38-0
Sample solution is provided at 25 µL, 10mM.
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4-Bromo-3-hydroxybenzoic acid is a metabolite of Brocresine and a histidine decarboxylase (HDC) inhibitor with IC50s of 1 mM for both rat fetal and rat gastric HDC. 4-Bromo-3-hydroxybenzoic acid also inhibits aromatic-L-amino acid decarboxylase from hog kidney and rat gastric mucosa in vitro with IC50s of 1 mM for both enzymes[1][2].
[1]. Ellenbogen L, et al. Studies on the inhibition of histidine decarboxylase, aromatic-L-amino acid decarboxylase and acid secretion by brocresine and its metabolites. Biochem Pharmacol. 1973 Apr 15;22(8):939-47. [2]. Qian S, et al. Inhibiting Histamine Signaling Ameliorates Vertigo Induced by Sleep Deprivation. J Mol Neurosci. 2019 Mar;67(3):411-417.
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