7-O-(Amino-PEG4)-paclitaxel |
| カタログ番号GC60033 |
7-O-(アミノ-PEG4)-パクリタキセルは、PROTAC の合成に使用できる PEG ベースの PROTAC リンカーです。
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Sample solution is provided at 25 µL, 10mM.
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7-O-(Amino-PEG4)-paclitaxel is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
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