α-Hydroxyglutaric Acid (Synonyms: 2-HG, 2-Hydroxyglutaric Acid) |
| カタログ番号GC18623 |
α-ヒドロキシグルタル酸 (2-ヒドロキシグルタル酸) は、α-グルタル酸のヒドロキシ酸型です。 α-ヒドロキシグルタル酸は、複数の α-ケトグルタル酸依存性ジオキシゲナーゼの競合阻害剤であり、ヒストン脱メチル化酵素や 5-メチルシトシン (5mC) 水酸化酵素の TET ファミリーが含まれます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2889-31-8
Sample solution is provided at 25 µL, 10mM.
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α-Hydroxyglutaric acid (2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate by D- and L-2-hydroxyglutarate dehydrogenases, and mutations in these enzymes lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased levels of L-2-hydroxyglutaric acid . 2-HG can also be metabolized from isocitrate by mutated forms of isocitrate dehydrogenase 1 (IDH1) and IDH2. 2-HG is structurally similar to α-ketoglutarate, the product of wild-type isocitrate dehydrogenases, and competitively inhibits α-ketoglutarate-dependent dioxygenases, including histone lysine demethylases and DNA hydroxylases.
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Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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