AMP-Deoxynojirimycin (Synonyms: AdamantanepentyldNM, AMP-DNJ, AMPdNM, N(5adamantane1ylmethoxypentyl)Deoxynojirimycin) |
| カタログ番号GC41406 |
脂質メッセンジャーであるセラミドは、グルコシルセラミド合成酵素（GCS）によってグルコシルセラミドに変換されます。
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Cas No.: 216758-20-2
Sample solution is provided at 25 µL, 10mM.
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The lipid messenger ceramide is converted to glucosylceramide by glucosylceramide synthase (GCS). In the reverse direction, non-lysosomal glucosylceramidase (GCase), also known as β-glucosidase 2 (BGD), cleaves the glucosyl moiety from glucosylceramide, liberating ceramide, which can be converted into sphingomyelin. AMP-deoxynojirimycin (AMP-dNM) is a hydrophobic derivative of dNM. It potently inhibits BGD (IC50 = 0.3 nM), less potently antagonizes GCS (IC50 = 25 nM), but only poorly inhibits other GCase isoforms. AMP-dNM has been shown to strongly suppress inflammation in a murine model of hapten-induced colitis, enhance insulin sensitivity in murine and rat models of insulin resistance, and induce sterol regulatory element-binding protein-regulated gene expression and cholesterol synthesis in HepG2 cells.
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