AT-9010 tetrasodium |
| カタログ番号GC63412 |
AT-527の三リン酸活性代謝物であるAT-9010テトラソディウムは、ウイルス複製に必要な機能であるNiRANを強力に阻害する。
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Cas No.: 1621884-18-1
Sample solution is provided at 25 µL, 10mM.
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AT-9010 tetrasodium, a triphosphate active metabolite of AT-527, is a potent inhibitor of NiRAN (a function essential for viral replication). AT-9010 tetrasodium can inhibit SARS-CoV-2 replication[1].
Substantial levels of the active triphosphate metabolite AT-9010 are formed in normal human bronchial and nasal epithelial cells incubated with 10 µM AT-511 (698 µM and 236 µM, respectively), with a half-life of at least 38 hours[1].
References:
[1]. Atea Pharmaceuticals Announces Publication of Preclinical Data Highlighting Potent Activity of AT-527 Against SARS-CoV-2. BOSTON, Feb. 08, 2021. Atea Pharmaceuticals, Inc.
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