AZD-8529 |
| カタログ番号GC31097 |
AZD-8529 は、285 nM の EC50 を持つ、mGluR2 の強力で高度に選択的で経口的に生物学的に利用可能なポジティブ アロステリック モジュレーターであり、mGluR1 に対して 20 ～ 25 M でポジティブ アロステリック モジュレーター応答を示しません, 3, 4, 5, 6, 7 、および 8 つのサブタイプ。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1092453-15-0
Sample solution is provided at 25 µL, 10mM.
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AZD-8529 is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.
AZD-8529 is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes. AZD8529 potentiates the effects of glutamate at mGluR2 with an EC50 of 195±62 nM[1].
AZD-8529 (0.3, 1 or 3 mg/kg, i.m.) reduces nicotine priming-induced and cue-induced reinstatement in squirrel monkeys. AZD-8529 (30 mg/kg) decreases the increased extracellular dopamine induced by nicotine in accumbens shell of freely-moving rats[1].
[1]. Justinova Z, et al. The Novel Metabotropic Glutamate Receptor 2 Positive Allosteric Modulator, AZD8529, Decreases Nicotine Self-Administration and Relapse in Squirrel Monkeys. Biol Psychiatry. 2015 Oct 1;78(7):452-62.
Average Rating: 5 (Based on Reviews and 35 reference(s) in Google Scholar.)
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