Bialaphos (sodium salt) (Synonyms: SF 1293) |
| カタログ番号GC14267 |
自然非選択的植物毒素
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 71048-99-2
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Bialaphos is a natural non-selective phytotoxin produced by certain Streptomyces species. It is a pro-toxin, a tripeptide that is converted in vivo to the active agent phosphinothricin, which is a glutamine analog.[1] L-Phosphinothricin inhibits glutamine synthetase (Ki = 6.1 µM), resulting in accumulation of ammonium and disruption of primary metabolism.[1],[2] The bacterial bar gene encodes a phosphinothricin acetyltransferase, which confers resistance to phosphinothricin.[3] Bialaphos is used in the selection of transgenic plants that express the bar gene, usually under the control of a constitutively active viral promoter.[3]
Reference:
[1]. Duke, S.O., and Dayan, F.E. Modes of action of microbially-produced phytotoxins. Toxins (Basel) 3(8), 1038-1064 (2011).
[2]. Ericson, M.C. Purification and properties of glutamine synthetase from spinach leaves. Plant Physiology 79(4), 923-927 (1985).
[3]. Block, M.D., Botterman, J., Vandewiele, M., et al. Engineering herbicide resistance in plants by expression of a detoxifying enzyme. EMBO Journal 6(9), 2513-2518 (1987).
Average Rating: 5 (Based on Reviews and 14 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *