BOLD-100 (Synonyms: NKP-1339 free base; IT-139 free base; KP-1339 free base) |
| カタログ番号GC65318 |
BOLD-100は、ルテニウムをベースとした抗がん剤です。BOLD-100はまた、ストレス誘発性GRP78の上昇を阻害することで、内質網（ER）のホメオスタシスを崩し、ERストレスおよびアンフォールドプロテイン応答（UPR）を引き起こします。BOLD-100は、ERストレス応答、リソソーム動態、およびオートファジー実行の複雑な相互作用に干渉します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 783324-98-1
Sample solution is provided at 25 µL, 10mM.
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BOLD-100 is a ruthenium-based anticancer agent. BOLD-100 also is an inhibitor of stress-induced GRP78 upregulation, disrupting endoplasmic reticulum (ER) homeostasis and inducing ER stress and unfolded protein response (UPR). BOLD-100 interferes with the complex interplay between ER-stress response, lysosome dynamics, and autophagy execution[1].
[1]. Baier D, et al. The Anticancer Ruthenium Compound BOLD-100 Targets Glycolysis and Generates a Metabolic Vulnerability towards Glucose Deprivation. Pharmaceutics. 2022;14(2):238. Published 2022 Jan 20.
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