C8 D-threo Ceramide (d18:1/8:0) (Synonyms: D-threo Cer(d18:1/8:0), D-threo Ceramide (d18:1/8:0), N-octanoyl-D-threo-Sphingosine) |
| カタログ番号GC43109 |
C8 D-スレオセラミドは、生物活性のあるスフィンゴ脂質であり、自然界に存在するセラミドの細胞浸透性アナログです。
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Cas No.: 175892-43-0
Sample solution is provided at 25 µL, 10mM.
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C8 D-threo Ceramide is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It is cytotoxic to U937 cells (IC50 = 17 μM) and induces nuclear DNA fragmentation 5- to 6-fold more potently than C8 ceramide . C8 D-threo Ceramide is a substrate for E. coli diacylglycerol kinase. It activates ceramide-activated protein kinase (CAPK) in U937 cells. C8 D-threo Ceramide also enhances V. cholerae cytolysin pore formation in liposome lipid membranes, as measured by calcein release, with a 50% release dose (RD50) value of ~5 μg/ml.
Average Rating: 5 (Based on Reviews and 39 reference(s) in Google Scholar.)
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