BPN14770 (Synonyms: BPN14770) |
| カタログ番号GC35543 |
BPN14770 (BPN14770) は選択的ホスホジエステラーゼ 4D (PDE4D) アロステリック阻害剤で、PDE4D7 と PDE4D3 の IC50 はそれぞれ 7.8 nM と 7.4 nM です。
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Cas No.: 1606974-33-7
Sample solution is provided at 25 µL, 10mM.
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BPN14770 is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC50s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively[1]. PDE4D3|7.4 nM (IC50)|PDE4D7|7.8 nM (IC50)
BPN14770 increases brain cAMP, increases phosphorylation of CREB and increases production of brain-derived neurotrophic factor (BDNF) in hippocampus[1].BPN14770 (0.1-30 mg/kg; p.o.; 24 hours) provides cognitive benefit in the mouse novel object recognition (NOR) at doses above 0.3 mg/kg[2]. Animal Model: C57Bl6 mice[2]
[1]. Ricciarelli R, et al. Memory-enhancing effects of GEBR-32a, a new PDE4D inhibitor holding promise for the treatment of Alzheimer's disease. Sci Rep. 2017 Apr 12;7:46320. [2]. Gurney ME, et al. Design and Synthesis of Selective Phosphodiesterase 4D (PDE4D) Allosteric Inhibitors for the Treatment of Fragile X Syndrome and Other Brain Disorders. J Med Chem. 2019 May 23;62(10):4884-4901.
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