Seltorexant hydrochloride (Synonyms: JNJ-42847922 hydrochloride) |
| カタログ番号GC61273 |
セルトレキサント塩酸塩 (JNJ-42847922 塩酸塩) は、経口活性、高親和性、選択的 OX2R アンタゴニスト (ヒトおよびラット OX2R の pKi 値 8.0 および 8.1) です。
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Cas No.: 1293284-49-7
Sample solution is provided at 25 µL, 10mM.
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Seltorexant hydrochloride (JNJ-42847922 hydrochloride) is an orally active, high-affinity, and selective OX2R antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant hydrochloride crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain[1].
Seltorexant hydrochloride (JNJ-42847922 hydrochloride) (3-30 mg/kg; p.o.) dose-dependently induces and prolongs sleep in male Sprague-Dawley rats[1].The sleep-promoting effects of Seltorexant hydrochloride (30 mg/kg; p.o.; per day for 7 days) are maintained upon 7-day repeated dosing in rats[1]. Animal Model: Male Sprague-Dawley rats (350-450 g)[1]
[1]. Bonaventure P, et al. Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia. J Pharmacol Exp Ther. 2015 Sep;354(3):471-82.
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