Tepoxalin (Synonyms: ORF 20485, RWJ 20485) |
| カタログ番号GC49386 |
テポキサリンは、COX と 5-リポキシゲナーゼ (5-LO) の二重阻害剤であり、強力な抗炎症作用と良好な胃腸プロファイルを備えています 。
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Cas No.: 103475-41-8
Sample solution is provided at 25 µL, 10mM.
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Tepoxalin is a dual inhibitor of COX and 5-lipoxygenase (5-LO; IC50s = 2.84 and 0.15 µM, respectively, in RBL-1 cell lysates).1 It also inhibits the activity of 12-, but not 15-, LO (IC50s = 4.45 and 146.6 µM for the human platelet and rabbit reticulocyte enzymes, respectively). Tepoxalin reduces the production of thromboxane B2 and leukotriene B4 induced by the calcium ionophore A23187 in human peripheral blood mononuclear cells (PBMCs; IC50s = 0.01 and 0.07 µM, respectively) and decreases epinephrine-induced platelet aggregation in human platelet-rich plasma (PRP; IC50 = 0.045 µM). It inhibits paw swelling in a rat model of adjuvant-induced arthritis with an ED50 value of 3.5 mg/kg.
1.Argentieri, D.C., Ritchie, D.M., Ferro, M.P., et al.Tepoxalin: A dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profileJ. Pharmacol. Exp. Ther.271(3)1399-1408(1994)
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