BTS (Synonyms: N-Benzyl-p-toluenesulfonamide, NSC 37123) |
| カタログ番号GC16189 |
BTS (N-ベンジル-p-トルエンスルホンアミド) は、骨格筋ミオシン II サブフラグメント 1 (S1) ATPase 活性の強力かつ選択的な阻害剤であり、アクチンおよび Ca2+- 刺激ミオシン S1 ATPase に対する IC50 は約 5 μM です。
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Cas No.: 1576-37-0
Sample solution is provided at 25 µL, 10mM.
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BTS is a potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 ~ 5 μM) and reversibly blocks the gliding motility. IC50 value: 5 uMTarget: Ca2+-stimulated myosin S1 ATPaseBTS also weakens myosin’s interaction with F-actin. BTS is much less effective in suppressing contraction in rat myocardial or rabbit slow twitch muscle and has no effect on platelet myosin II.
References:
[1]. Cheung A, et al. A small-molecule inhibitor of skeletal muscle myosin II. Nat Cell Biol. 2002 Jan;4(1):83-8.
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