HDAC-IN-4 (Synonyms: AZD 9468) |
| カタログ番号GC19190 |
HDAC-IN-4 は、HDAC1、HDAC2、および HDAC3 に対してそれぞれ 63 nM、570 nM、および 550 nM の IC50 を持つ強力で選択的な経口活性クラス I HDAC 阻害剤です。 HDAC-IN-4 は、HDAC クラス II に対して活性がありません。 HDAC-IN-4 には抗腫瘍活性があります。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 934828-12-3
Sample solution is provided at 25 µL, 10mM.
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CXD101 is a class I-selective HDAC inhibitor (HDAC1 (IC50, 63 nM), HDAC2 (IC50, 570 nM), HDAC3 (IC50, 550 nM). CXD101 has no activity against HDAC class II[1].
References:
[1]. Eyre TA, et al. Predictive biomarkers for disease sensitivity in lymphoma - the holy grail for HDAC inhibitors Oncotarget. 2018 Dec 18;9(99):37280-37281.
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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