GLX351322 |
| カタログ番号GC31367 |
GLX351322 は NADPH オキシダーゼ 4 (Nox4) の阻害剤であり、NOX4 過剰発現細胞からの過酸化水素産生を 5 μM の IC50 で阻害します。
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Cas No.: 835598-94-2
Sample solution is provided at 25 µL, 10mM.
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GLX351322 is an inhibitor of NADPH oxidase 4, and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μ M.
GLX351322 is an inhibitor of NADPH oxidase 4, and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μM. GLX351322 shows weak activity against NOX2 in hPBMC cells (IC50, 40 μM).
GLX351322 (3.8 mg/kg/day, p.o.) ameliorates HFD-induced hyperglycemia in mice[1].
[1]. Anvari E, et al. The novel NADPH oxidase 4 inhibitor GLX351322 counteracts glucose intolerance in high-fat diet-treated C57BL/6 mice. Free Radic Res. 2015;49(11):1308-18.
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