GN44028 |
| カタログ番号GC34595 |
GN44028 は、強力な経口活性低酸素誘導因子 (HIF)-1α 阻害剤であり、IC50 は 14 nM です。 GN44028 は、HIF-1α mRNA 発現、HIF-1α タンパク質蓄積、または HIF-1α/HIF-1β ヘテロ二量体化を抑制することなく、低酸素誘導 HIF-1α 転写活性を阻害します。 GN44028 は癌の研究に使用できます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1421448-26-1
Sample solution is provided at 25 µL, 10mM.
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GN44028 is a hypoxia inducible factor (HIF)-1 inhibitor, with an IC50 of 14 nM. GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity without suppressing HIF-1α mRNA expression, HIF-1α protein accumulation, or HIF-1α/HIF-1β heterodimerization[1]. IC50: 14 nM (HIF-1)[1].
[1]. Minegishi H, et al. Discovery of Indenopyrazoles as a New Class of Hypoxia Inducible Factor (HIF)-1 Inhibitors. ACS Med Chem Lett. 2013 Jan 27;4(2):297-301.
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