Sphinganine-1-phosphate (d18:0) (Synonyms: C18-dihydro Sphingosine-1-phosphate, D-erythro-Sphinganine-1-phosphate, dihydro-D-erythro-Sphingosine-1-phosphate) |
| カタログ番号GC44927 |
スフィンガニン-1-リン酸 (d18:0) (D-エリトロ-ジヒドロスフィンゴシン 1-リン酸) は、細胞の移動、分化、生存および複雑な生理学的プロセスを調節する極性スフィンゴ脂質代謝産物です。
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Cas No.: 19794-97-9
Sample solution is provided at 25 µL, 10mM.
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Sphinganine-1-phosphate is an intermediate in the metabolism of glycosphingolipids and sphingolipids. It acts as an antagonist at the sphingosine-1-phosphate (S1P1/EDG-1) receptor (Ki = 15 nM). Sphinganine-1-phosphate prevents liver and kidney damage following hepatic ischemia and reperfusion injury in mice at doses lower than 0.1 and 0.2 mg/kg when administered prior to or following reperfusion, respectively. It has antifibrotic effects in scleroderma fibroblasts through normalization of PTEN protein levels, collagen and matrix metalloproteinase-1 (MMP-1) expression, and Smad3 phosphorylation.
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