Sulfosuccinimidyl Oleate (sodium salt) (Synonyms: SSO) |
カタログ番号GC44971 |
スルホスクシニミジルオレート(SSO)は、脂肪酸トランスロケーゼCD36の不可逆的な阻害剤であり、アディポサイトに200μM添加すると、オレイン酸、リノール酸、またはステアリン酸の取り込みを約65%ブロックします。
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Sample solution is provided at 25 µL, 10mM.
Sulfosuccinimidyl oleate (SSO) is an irreversible inhibitor of the fatty acid translocase CD36, blocking uptake of oleate, linoleate, or stearate by about 65% when added at 200 µM to adipocytes.[1],[2] It reduces the uptake of palmitate by mouse insulinoma MIN6 cells, preventing palmitate-induced changes in insulin secretion.[3] SSO impairs saturated fatty acid-induced lipid accumulation and inflammation in RAW 264.7 macrophages.[4]
Reference:
[1]. Harmon, C.M., Luce, P., Beth, A.H., et al. Labeling of adipocyte membranes by sulfo-N-succinimidyl derivatives of long-chain fatty acids: Inhibition of fatty acid transport. J.Membrane Biol. 121, 261-268 (1991).
[2]. Abumrad, N.A., el-Maghrabi, M.R., Amri, E.Z., et al. Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36. The Journal of Biological Chemisty 268(24), 17665-17668 (1993).
[3]. Noushmehr, H., D'Amico, E., Farilla, L., et al. Fatty acid translocase (FAT/CD36) is localized on insulin-containing granules in human pancreatic β-cells and mediates fatty acid effects on insulin secretion. Diabetes 54(2), 472-481 (2005).
[4]. Nicholls, H.T., Kowalski, G., Kennedy, D.J., et al. Hematopoietic cell-restricted deletion of CD36 reduces high-fat diet-induced macrophage infiltration and improves insulin signaling in adipose tissue. Diabetes 60(4), 1100-1110 (2011).
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