(±)11(12)-EET Ethanolamide (Synonyms: (±)11,12-EpETrE Ethanolamide) |
| カタログ番号GC45271 |
アラキドノイルエタノールアミド（AEA; アナンダミド）は、中枢カンナビノイド（CB1）および末梢カンナビノイド（CB2）受容体の両方に結合するカンピング作用を持つ内因性脂質神経伝達物質です。
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Arachidonoyl ethanolamide (AEA; anandamide) is an endogenous lipid neurotransmitter with cannibingeric activity, binding to both the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. Fatty acid amide hydrolase (FAAH) is the enzyme responsible for the hydrolysis and inactivation of AEA. Metabolism of AEA by cyclooxygenase-2, leading to formation of prostaglandin ethanolamides, and by lipoxygenases has also been documented. (±)11(12)-EET ethanolamide is a potential cytochrome P450 (CYP450) metabolite of AEA, although specific stereochemistry rather than a racemic mixture would likely ensue from enzymatic metabolism. CYP450 metabolism of AEA may be particularly relevant under conditions of FAAH inhibition. Evidence for the formation of (±)11(12)-EET ethanolamide in vivo has not been documented.
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