CAY10462 |
| カタログ番号GC43158 |
20-HETEは、特に腎臓で合成されるシトクロムP450（CYP450）4Aファミリーの酵素によってアラキドン酸の重要な代謝物です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 502656-68-0
Sample solution is provided at 25 µL, 10mM.
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20-HETE is an important metabolite of arachidonic acid in the vasculature, especially in the kidney, where it is synthesized by cytochrome P450 (CYP450) enzymes of the 4A family. Alkylaryl imidazoles have been shown to inhibit certain CYP450 enzymes, including the CYP4A enzymes associated with 20-HETE synthesis. CAY10462 is the hydrochloride salt of CAY10434 and selective inhibitor of the 20-HETE synthase CYP4A11 exhibiting an IC50 of 8.8 nM when tested in human renal microsomes. CAY10434 is nearly 200 times less potent as an inhibitor of 1A, 1C, and 3A CYP450 enzymes.
Average Rating: 5 (Based on Reviews and 10 reference(s) in Google Scholar.)
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