CAY10535 |
| カタログ番号GC43166 |
TPαとTPβは、トロンボキサンA2（TXA2）の作用を仲介するGタンパク質共役受容体（GPCR）である人間のTP受容体の2つのアイソフォームです。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 945716-28-9
Sample solution is provided at 25 µL, 10mM.
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TPα and TPβ are two isoforms of the human TP receptor, the G protein-coupled receptor (GPCR) that mediates the actions of thromboxane A2 (TXA2). Although their distinct physiological functions have not been fully elucidated, TPβ is believed to be responsible for vascular endothelial growth factor-induced endothelial cell differentiation and migration whereas TPα appears to be the predominant isoform expressed in platelets. CAY10535 is a TP receptor antagonist that shows ~20-fold selectivity for TPβ (IC50 = 99 nM) relative to TPα (IC50 = 1,970 nM) in the inhibition of U46619-mediated Ca2+ mobilization. This compound exhibits relatively poor activity on platelets (IC50 = 985 nM) when inhibiting U-46619-induced platelet aggregation.
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