CAY10589 |
| カタログ番号GC18688 |
マイクロソーマルプロスタグランジンE2合成酵素-1（mPGES-1）は、シクロオキシゲナーゼ-2（COX-2）と共にPGE2を合成し、炎症、発熱、痛みのサインに直接関与しています。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1077626-52-8
Sample solution is provided at 25 µL, 10mM.
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Microsomal Prostaglandin E2 Synthase-1 (mPGES-1), with cyclooxygenase-2 (COX-2), synthesizes PGE2, which is directly involved in signaling during inflammation, fever and pain. 5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs), which are pro-inflammatory mediators. CAY10589 is a dual inhibitor of mPGES-1 (IC50 = 1.3 μM) and 5-LO (IC50 = 1.0 μM). It effectively inhibits PGE2 and LT synthesis in both cell free and intact cell assays. CAY10589 has minor effects on COX-1 and COX-2, inhibiting these enzymes 34% and 38.8%, respectively, at 10 μM.
Review for CAY10589
Average Rating: 5 (Based on Reviews and 25 reference(s) in Google Scholar.)
Review for CAY10589
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