Corin |
| カタログ番号GC34165 |
Corin は、ヒストン リジン特異的脱メチル化酵素 (LSD1) とヒストン脱アセチル化酵素 (HDAC) の二重阻害剤であり、LSD1 の Ki(inact) は 110 nM、HDAC1 の IC50 は 147 nM です。
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Cas No.: 1808113-09-8
Sample solution is provided at 25 µL, 10mM.
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Corin is a dual inhibitor of histone lysine specific demethylase (LSD1) and histone deacetylase (HDAC), with a Ki(inact) of 110 nM for LSD1 and an IC50 of 147 nM for HDAC1.
Corin is able to inhibit the deacetylation of semisynthetic, reconstituted nucleosomes by the CoREST ternary complex. Corin shows irreversible inhibition of HDAC1 activity. In Comparison to MS-275, corin appears to more potently (Corin EC50 95 nM vs. MS-275 EC50 420 nM) and efficaciously induce cellular H3K9 acetylation. Interestingly, Corin (1 μM) is non-toxic to primary human melanocytes in contrast to MS-275 (1 μM)[1].
[1]. Kalin JH, et al. Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors. Nat Commun. 2018 Jan 4;9(1):53.
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