CRBN-6-5-5-VHL |
| カタログ番号GC50619 |
CRBN-6-5-5-VHL は、1.5 nM の DC50 値を持つ、強力かつ選択的なフォン ヒッペル-リンダウ ベースのセレブロン (CRBN) 分解剤です。 CRBN-6-5-5-VHL は、ネオ基質 IKZF1 および IKZF3 の分解にほとんど影響を与えません。
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Cas No.: 2362575-45-7
Sample solution is provided at 25 µL, 10mM.
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Potent and selective cereblon degrader (DC50 = 1.5 nM). Induces complete degradation of cereblon in MM1S cells. Comprises a cereblon E3 ligase ligand joined by a linker to a ligand for the E3 ligase VHL. Cell-permeable.
Steinebach et al (2019) PROTAC-mediated crosstalk between E3 ligases. Chem.Commun.(Camb) 55 1821 PMID:30672516
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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