PROTAC ER Degrader-2 |
カタログ番号GC34733 |
PROTAC ER Degrader-2 は、PAC 合成の中間体です。 PAC は、抗体に結合した ADC リンカーと PROTAC で構成されます。 PAC は、特許 WO2017201449A1、化合物 LP2 から抽出します。抗体に結合した PAC は、PROTAC (Ab なし) と比較して、より顕著なエストロゲン受容体-アルファ (ERα) 分解因子です。
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Cas No.: 1351169-29-3
Sample solution is provided at 25 µL, 10mM.
PROTAC ER Degrader-2 is an intermediate for synthesis of PAC. PAC comprises an antibody conjugated via a linker to a PROTAC. PAC extracts from patent WO2017201449A1, compound LP2. PAC is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab).
[1]. Thomas Pillow, et al. Protac antibody conjugates and methods of use. WO2017201449A1.
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