Epirubicin HCl (Synonyms: 4’Epidoxorubicin) |
カタログ番号GC10686 |
ドキソルビシンの半合成 L-アラビノ誘導体であるエピルビシン HCl (4'-エピドキソルビシン塩酸塩) は、トポイソメラーゼを阻害することによって抗腫瘍剤を持っています。 Epirubicin HCl は、DNA および RNA 合成を阻害します。 Epirubicin HCl は Forkhead box protein p3 (Foxp3) 阻害剤であり、制御性 T 細胞の活性を阻害します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 56390-09-1
Sample solution is provided at 25 µL, 10mM.
Epirubicin is an inhibitor of DNA topoisomerase (TOPII) [1].
Epirubicin belongs to the Anthracylines chemical class, it is a sort of DNA topoisomerase poison. It can inhibit the religation step of DNA topology, resulting in stabilization of the 5’ phosphotyrosyl-DNA complex (cleavage complex). These lesions are cytotoxic and lead to activation of the DNA damage response and potentially apoptosis. Because of this, it is usually used in cancer therapy. Unfortunately, it also has genotoxic side effects, including the formation of leukemogenic chromosome translocations [1].
Epirubicin is one of the chemotherapeutic agents used for the treatment of Osteosarcoma. It exhibits growth inhibition of tumors by inducing apoptosis. Conversely, it reduces apoptosis in OS cells by activating NF-κB. It is reported that epirubicin combined with cerulenin can enhance the anti-tumor activity in vitro and in vivo [2].
References:
[1] Ian G. Cowell, Caroline A. Austin. Mechanism of Generation of Therapy Related Leukemia in Response to Anti-Topoisomerase II Agents. International Journal of Environmental Research and Public Health. 2012 (9): 2075-2091.
[2] Z.L. LIU, G. WANG, Y. SHU, P.A. ZOU, Y. ZHOU and Q.S. YIN. Enhanced antitumor activity of epirubicin combined with cerulenin in osteosarcoma. Molecular Medicine Reports. 2012 (5): 326-330.
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