Gallocyanine (Synonyms: IIIC3, Alizarine Navy Blue, Anthracene Blue SWGG, Brilliant Chrome Blue P, C.I. 51030, Fast Violet, Mordant Blue 10) |
| カタログ番号GC43725 |
合成青色染料であるガロシアニンは、DKK1/LRP6 相互作用を妨害することにより、DKK1 阻害活性をブロックします。
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Cas No.: 1562-85-2
Sample solution is provided at 25 µL, 10mM.
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Gallocyanine is a small molecule blue dye used to stain nuclei. It is known to inhibit Dickkopf-1 (Dkk1), an antagonist of the Wnt pathway. Gallocyanine can disrupt the interaction of Dkk1 with its receptor LRP5/6 (IC50 = 3 µM), thereby activating Wnt/β-catenin signaling. Modulation of the Dkk1-LRP5/6 interaction via gallocyanine has been shown to inhibit prostaglandin J2-induced tau phosphorylation at serine396 in primary cortical neurons in vitro.
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