Curzerene |
| カタログ番号GC35759 |
Curzerene は、Curculigo orchioides Gaertn の根茎から分離されたセスキテルペンで、抗がん作用があります。カーゼレンは、グルタチオン S-トランスフェラーゼ A1 (GSTA1) mRNA およびタンパク質の発現を阻害します。カーゼレンは細胞アポトーシスを誘導します。
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Cas No.: 17910-09-7
Sample solution is provided at 25 µL, 10mM.
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Curzerene is a sesquiterpene is isolated from the rhizome of Curculigo orchioides Gaertn with anti-cancer activity. Curzerene inhibits glutathione S-transferase A1 (GSTA1) mRNA and protein expression. Curzerene induces cell apoptosis[1]. GSTA1[1]
Curzerene (0-100 µM; 24-72 hours) indicates that cell inhibition increases in a dose- and time-dependent manner, IC50 to SPC A1 cells at 24, 48, and 72 h was 403.8 μM, 154.8 µM, and 47.01 µM, respectively[1].Curzerene (0-100 µM; 48 hours) exhibits a higher percentage of apoptotic and necrotic cells than that of the control group in SPC-A1cells[1].Curzerene(0-100 µM; 48 hours) indicates that the percentage of cells arrested in the G2/M phase increased from 9.26% in the control group cells to 17.57% in the cells treated with the highest dose[1].Curzerene (6.25-100 µM; 48 hours) decreases the mRNA expression of GSTA1 in SPC A1 cells[1].Curzerene (6.25-100 µM; 48 hours) decreases the protein expression of GSTA1 in SPC A1 cells[1]. Cell Viability Assay[1] Cell Line: SPC-A1 cells
[1]. Wang Y, et al. Cytotoxic and Antitumor Effects of Curzerene from Curcuma longa. Planta Med. 2017 Jan;83(1-02):23-29.
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