Curzerene |
| Catalog No.GC35759 |
Curzerene is a sesquiterpene is isolated from the rhizome of Curculigo orchioides Gaertn with anti-cancer activity. Curzerene inhibits glutathione S-transferase A1 (GSTA1) mRNA and protein expression. Curzerene induces cell apoptosis.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 17910-09-7
Sample solution is provided at 25 µL, 10mM.
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Curzerene is a sesquiterpene is isolated from the rhizome of Curculigo orchioides Gaertn with anti-cancer activity. Curzerene inhibits glutathione S-transferase A1 (GSTA1) mRNA and protein expression. Curzerene induces cell apoptosis[1]. GSTA1[1]
Curzerene (0-100 µM; 24-72 hours) indicates that cell inhibition increases in a dose- and time-dependent manner, IC50 to SPC A1 cells at 24, 48, and 72 h was 403.8 μM, 154.8 µM, and 47.01 µM, respectively[1].Curzerene (0-100 µM; 48 hours) exhibits a higher percentage of apoptotic and necrotic cells than that of the control group in SPC-A1cells[1].Curzerene(0-100 µM; 48 hours) indicates that the percentage of cells arrested in the G2/M phase increased from 9.26% in the control group cells to 17.57% in the cells treated with the highest dose[1].Curzerene (6.25-100 µM; 48 hours) decreases the mRNA expression of GSTA1 in SPC A1 cells[1].Curzerene (6.25-100 µM; 48 hours) decreases the protein expression of GSTA1 in SPC A1 cells[1]. Cell Viability Assay[1] Cell Line: SPC-A1 cells
[1]. Wang Y, et al. Cytotoxic and Antitumor Effects of Curzerene from Curcuma longa. Planta Med. 2017 Jan;83(1-02):23-29.
| Cas No. | 17910-09-7 | SDF | |
| Canonical SMILES | C=C([C@H]([C@@](C)(C=C)C1)CC2=C1OC=C2C)C | ||
| Formula | C15H20O | M.Wt | 216.32 |
| Solubility | DMSO: 250 mg/mL (1155.70 mM) | Storage | -20°C, protect from light, stored under nitrogen,unstable in solution, ready to use. |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 4.6228 mL | 23.1139 mL | 46.2278 mL |
| 5 mM | 0.9246 mL | 4.6228 mL | 9.2456 mL |
| 10 mM | 0.4623 mL | 2.3114 mL | 4.6228 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 13 reference(s) in Google Scholar.)
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