E3 ligase Ligand 12 (Synonyms: E3 ligase Ligand 12) |
| カタログ番号GC35926 |
E3 リガーゼ リガンド 12 は、LCL161 誘導体ベースの IAP リガンドです。 E3 リガーゼ リガンド 12 は、リンカーによってタンパク質に対する ABL リガンドに接続され、SNIPER を形成します。
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Cas No.: 2095244-42-9
Sample solution is provided at 25 µL, 10mM.
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E3 ligase Ligand 12 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 12 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
[1]. Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575.
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