mPGES1-IN-3 |
| カタログ番号GC36649 |
mPGES1-IN-3 (化合物 17d) は、強力かつ選択的なミクロソーム プロスタグランジン E2 シンターゼ-1 (mPGES-1) 阻害剤であり、優れた mPGES-1 酵素 (IC50: 8 nM)、細胞 (A549 IC50: 16.24 nM) およびヒト全血効力 (IC50: 249.9 nM)。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1469976-70-2
Sample solution is provided at 25 µL, 10mM.
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mPGES1-IN-3 (Compound 17d) is a potent and selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor, which exhibits excellent mPGES-1 enzyme (IC50: 8 nM), cell (A549 IC50: 16.24 nM) and human whole blood potency (IC50: 249.9 nM)[1]. IC50: 8 nM (mPGES-1)[1]
[1]. Muthukaman N, et al. Discovery of 2-((2-chloro-6-fluorophenyl)amino)-N-(3-fluoro-5-(trifluoromethyl)phenyl)-1-methyl-7,8-dihydro-1H-[1,4]dioxino[2',3':3,4]benzo[1,2-d]imidazole-5-carboxamide as potent, selective and efficacious microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5977-5984.
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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