Rac-PT2399 |
| カタログ番号GC37066 |
ＰＴ２３９９のラセミ体であるＲａｃ－ＰＴ２３９９（化合物１０ｅ）は、強力かつ特異的な低酸素誘導因子２ａ（ＨＩＦ－２α）阻害剤として作用し、ＩＣ５０は０．０１μＭである。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1672662-07-5
Sample solution is provided at 25 µL, 10mM.
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Rac-PT2399 (Compound 10e), the racemate of PT2399, acts as a potent and specific hypoxia-inducible factor 2a (HIF-2α) inhibitor with an IC50 of 0.01 μM[1]. IC50: 0.01 μM (HIF-2α)[1]
[1]. Wehn PM, et al. Design and Activity of Specific Hypoxia-Inducible Factor-2α (HIF-2α) Inhibitors for the Treatment of Clear Cell Renal Cell Carcinoma: Discovery of Clinical Candidate (S)-3-((2,2-Difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1 H-inden-4-yl)oxy)-5-fluorobenzonitrile (PT2385). J Med Chem. 2018 Nov 8;61(21):9691-9721.
Average Rating: 5 (Based on Reviews and 8 reference(s) in Google Scholar.)
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