REV7/REV3L-IN-1 |
カタログ番号GC37520 |
REV7/REV3L-IN-1 は、78 μM の IC50 を持つ REV7/REV3L 相互作用阻害剤であり、核磁気共鳴分析で REV7 に直接結合し、鎖間架橋 (ICL) を含むレポーター プラスミドの再活性化を阻害します。プロモーターおよびレポーター領域。
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Cas No.: 1979192-13-6
Sample solution is provided at 25 µL, 10mM.
REV7/REV3L-IN-1 is a REV7/REV3L interaction inhibitor with an IC50 of 78 μM, which directly binds to REV7 in nuclear magnetic resonance analyses, and inhibits the reactivation of a reporter plasmid containing an interstrand crosslink (ICL) in between the promoter and reporter regions[1]. IC50: 78 μM (REV7/REV3L interaction)[1]
[1]. Actis ML, et al. Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction. Bioorg Med Chem. 2016 Sep 15;24(18):4339-4346.
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