REV7/REV3L-IN-1 |
| Katalog-Nr.GC37520 |
REV7/REV3L-IN-1 ist ein REV7/REV3L-Interaktionsinhibitor mit einem IC50-Wert von 78 μM, der in Kernspinresonanzanalysen direkt an REV7 bindet und die Reaktivierung eines Reporterplasmids hemmt, das dazwischen eine Interstrang-Vernetzung (ICL) enthÄlt Promoter- und Reporterregionen.
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Cas No.: 1979192-13-6
Sample solution is provided at 25 µL, 10mM.
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REV7/REV3L-IN-1 is a REV7/REV3L interaction inhibitor with an IC50 of 78 μM, which directly binds to REV7 in nuclear magnetic resonance analyses, and inhibits the reactivation of a reporter plasmid containing an interstrand crosslink (ICL) in between the promoter and reporter regions[1]. IC50: 78 μM (REV7/REV3L interaction)[1]
[1]. Actis ML, et al. Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction. Bioorg Med Chem. 2016 Sep 15;24(18):4339-4346.
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