Barbadin |
| カタログ番号GC38351 |
バルバジンは新規の選択的β-アレスチン/β2-アダプチン相互作用阻害剤であり、β-アレスチン1で19.1 μM、β-アレスチン2で15.6 μMのIC50値を持っています。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 356568-70-2
Sample solution is provided at 25 µL, 10mM.
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Barbadin is a novel and selective β-arrestin/β2-adaptin interaction inhibitor, has IC50 values of 19.1 μM for β-arrestin1 and 15.6 μM for β-arrestin2. Barbadin blocks agonist-promoted endocytosis of the prototypical β2-adrenergic, V2-vasopressin and angiotensin-II type-1 receptors[1].
[1]. Beautrait A, et al. A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling. Nat Commun. 2017 Apr 18;8:15054. doi: 10.1038/ncomms15054.
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