Apamin TFA (Synonyms: Apamine TFA) |
| カタログ番号GC38557 |
アパミン TFA (アパミン TFA) は、アピトキシン (ハチ毒) に含まれる 18 アミノ酸のペプチド神経毒であり、Ca2+- 活性化 K+ (SK) チャネルの特異的な選択的ブロッカーとして知られており、抗炎症作用と抗炎症作用を示します。抗線維化活動。
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Sample solution is provided at 25 µL, 10mM.
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Apamin TFA (Apamine TFA) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca2+-activated K+ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity[1].
Apamin (0.5-2 µg/mL; 24 hours; HSC-T6 cells) treatment markedly reduces the expression of α-SMA in the TGF-β1-induced HSC-T6 cells. Apamin treatment abrogats the activation of p-Smad2/3 and Smad4 induced by TGF-β1[1]. Western Blot Analysis[1] Cell Line: HSC-T6 cells
Apamin (0.1 mg/kg; intraperitoneal injection; twice a week; for 4 weeks; C57BL/6 male mice) treatment results in decreased liver injury and proinflammatory cytokine levels. Apamin suppresses the deposition of collagen, proliferation of BECs and expression of fibrogenic genes in the 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-fed mice[1]. Animal Model: 8-week-old C57BL/6 male mice (20-25 g) with DDC feeding[1]
[1]. Kim JY, et al. Apamin suppresses biliary fibrosis and activation of hepatic stellate cells. Int J Mol Med. 2017 May;39(5):1188-1194.
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