Glycoursodeoxycholic acid (Ursodeoxycholylglycine) (Synonyms: GUDCA, Ursodeoxycholyl Glycine) |
| カタログ番号GC33687 |
アシルグリシンおよび胆汁酸-グリシンコンジュゲートであるグリコルデオキシコール酸（ウルソデオキシコリルグリシン）は、ウルソデオキシコール酸の代謝産物です。
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Cas No.: 64480-66-6
Sample solution is provided at 25 µL, 10mM.
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Glycoursodeoxycholic acid, a acyl glycine and a bile acid-glycine conjugate, is a metabolite of ursodeoxycholic acid.In Vitro: The antioxidant compound glycoursodeoxycholic acid (GUDCA) fully abrogates UCB-induced cytochrome c oxidase inhibition and significantly prevents oxidative stress, metabolic alterations, and cell demise[1].GUDCA has shown therapeutic efficacy in neurodegenerative models and diseases. Increased cytosolic SOD1 inclusions were observed in 4 DIV NSC-34/hSOD1(G93A) cells together with decreased mitochondria viability, caspase-9 activation, and apoptosis[2]. Glycoursodeoxycholic acid shows preventive and restorative effects against unconjugated bilirubin -induced blood-brain barrier disruption and damage to human brain microvascular endothelial cells[3].
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