Ibotenic acid (Synonyms: NSC 204850) |
| カタログ番号GC11715 |
イボテン酸は、N-メチル-D-アスパラギン酸 (NMDA) およびトランス ACPD またはメタボロピック キスカル酸 (Qm) 受容体部位の両方でアゴニスト活性を持っています。
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Cas No.: 2552-55-8
Sample solution is provided at 25 µL, 10mM.
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Ibotenic acid has agonist activity at both the N-methyl-D-aspartate (NMDA) and trans-ACPD or metabolotropic quisqualate (Qm) receptor sites.
Ibotenic acid (Ibo) is capable of acting at both NMDA and trans-ACPD receptors in the CNS, although only activation of NMDA receptors is involved in Ibo neurotoxicity. Ibotenic acid is toxic to cortical neurons exposes for 5 min with an EC50=77.3±8 μM (n=5) as measured by release of lactate dehydrogenase to the culture media[1].
References:
[1]. Zinkand WC, et al. Ibotenic acid mediates neurotoxicity and phosphoinositide hydrolysis by independent receptormechanisms. Mol Chem Neuropathol. 1992 Feb-Apr;16(1-2):1-10.
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