Ketorolac (calcium salt) |
| カタログ番号GC47528 |
ケトロラック (RS37619) ヘミカルシウムは非ステロイド性抗炎症薬 (NSAID) であり、非選択的な COX 阻害剤として作用し、COX-1 の IC50 は 20 nM、COX-2 の IC50 は 120 nM です。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 167105-81-9
Sample solution is provided at 25 µL, 10mM.
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Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) and a non-selective COX inhibitor (IC50 = 20 nM for both COX-1 and COX-2).1 It prevents increases in paw swelling, increases paw withdrawal latency in a hot-plate test, and decreases prostaglandin E2 (PGE2) levels in paw tissue in a mouse model of carrageenan-induced inflammation when administered at a dose of 30 mg/kg. Ketorolac is a racemic mixture containing the active (S)-ketorolac and inactive (R)-ketorolac enantiomers. Formulations containing ketorolac have been used to manage postoperative pain and as ophthalmic solutions to treat ocular pain and inflammation.
1.Zhang, Y., Shaffer, A., Portanova, J., et al.Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 productionJ. Pharmacol. Exp. Ther.283(3)1069-1075(1997)
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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