Lacidipine (Synonyms: GX 1048, GR 43659X) |
| Katalog-Nr.GC15550 |
Lacidipin ist ein oral aktiver und hochselektiver Calciumkanalblocker vom L-Typ, der auf die CalciumkanÄle der glatten Muskulatur wirkt, hauptsÄchlich periphere Arterien erweitert, den peripheren Widerstand verringert und eine lang anhaltende blutdrucksenkende Wirkung hat.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 103890-78-4
Sample solution is provided at 25 µL, 10mM.
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Lacidipine (Lacipil, Motens) is a L-type calcium channel blocker. Target: Calcium ChannelLacidipine, a novel third-generation dihydropyridine calcium channel blocker, has been demonstrated effective for hypertension. lacidipine protects HKCs against apoptosis induced by ATP depletion and recovery by regulating the caspase-3 pathway [1]. In biological membranes deriving from rat brain tissue, lacidipine showed an activity comparable to reference antioxidant compounds like vitamin E [2]. lacidipine has some important protective effects on liver of hypertensive irradiated albino rats [3].
References:
[1]. Zhang, A., et al., Lacidipine attenuates apoptosis via a caspase-3 dependent pathway in human kidney cells. Cell Physiol Biochem, 2013. 32(4): p. 1040-9.
[2]. van Amsterdam, F.T., et al., Lacidipine: a dihydropyridine calcium antagonist with antioxidant activity. Free Radic Biol Med, 1992. 12(3): p. 183-7.
[3]. Kamal, S.M., Possible hepatoprotective effects of lacidipine in irradiated DOCA-salt hypertensive albino rats. Pak J Biol Sci, 2013. 16(21): p. 1353-7.
Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)
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