Liproxstatin-1 hydrochloride |
| カタログ番号GC50345 |
リプロキシスタチン-1 塩酸塩は強力なフェロトーシス阻害剤であり、フェロトーシス細胞死を阻害します (IC50=22 nM)。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2250025-95-5
Sample solution is provided at 25 µL, 10mM.
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Potent ferroptosis inhibitor (IC50 = 22 nM). Protects human renal proximal tubule cells from 1S,3R-RSL3 (Cat.No. 6118) -induced cell death in vitro. Inhibits acute renal failure and prolongs survival in Gpx4 knockdown mice. Also mitigates tissue damage in an in vivo hepatic ischemia/reperfusion model.
Friedmann Angeli et al (2014) Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat.Cell.Biol. 16 1180 PMID:25402683
Average Rating: 5 (Based on Reviews and 16 reference(s) in Google Scholar.)
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