LTV-1 |
| カタログ番号GC32852 |
LTV-1 は、T 細胞における強力なリンパ系チロシンホスファターゼ (LYP) 阻害剤であり、IC50 は 508 nM です。
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Cas No.: 347379-29-7
Sample solution is provided at 25 µL, 10mM.
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LTV-1 is a highly potent, cell-permeable and reversible inhibitor of lymphoid tyrosine phosphatase (LYP) (IC50 = 508 nM). IC50 value: 508 nMTarget: LYPin vitro: LTV-1 inhibits LYP in a dose-dependent manner at low- and sub-micromolar concentrations in T cells. LTV-1 enhances TCR signaling in intact cells. Exhibits competitive to mixed mode of inhibition (Ki = 384 nM). LTV-1 inhibits the mutant, disease associated LYP-Trp620 activity. LTV-1 blocks the action of the mutant LYP protein in human T cells.
[1]. Vang T, et al. LYP inhibits T-cell activation when dissociated from CSK. Nat Chem Biol. 2012 Mar 18;8(5):437-446.
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