Malachite green oxalate |
| Katalog-Nr.GC61021 |
MalachitgrÜnoxalat ist ein Triphenylmethanfarbstoff, der zum Nachweis der Phosphatfreisetzung bei enzymatischen Reaktionen verwendet werden kann. MalachitgrÜnoxalat ist auch ein potenter und selektiver Inhibitor von IKBKE und hemmt seine nachgeschalteten Ziele wie IκBα, p65 und IRF3. MalachitgrÜnoxalat zeigt AntitumoraktivitÄt in vitro und in vivo.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2437-29-8
Sample solution is provided at 25 µL, 10mM.
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Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions. Malachite green oxalate is also a potent and selective inhibitor of IKBKE, and inhibits its downstream targets such as IκBα, p65 and IRF3. Malachite green oxalate exhibits antitumor activity in vitro and in vivo[1][2][3].
[1]. Kozuka S, et, al. Permeability of dormant spores of Bacillus subtilis to malachite green and crystal violet. J Gen Microbiol. 1991 Mar; 137(3): 607-13. [2]. Takahashi S, et, al. Reversible off-on fluorescence probe for hypoxia and imaging of hypoxia-normoxia cycles in live cells. J Am Chem Soc. 2012 Dec 5; 134(48): 19588-91. [3]. Liu T, et, al. Identification of an IKBKE inhibitor with antitumor activity in cancer cells overexpressing IKBKE. Cytokine. 2019 Apr; 116: 78-87.
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