Microcystin-LA (Synonyms: CyanoginosinLA, Toxin BE4 (M. aeruginosa)) |
| カタログ番号GC18859 |
天然毒素であるミクロシスチン LA は、セリン - スレオニンタンパク質ホスファターゼ PP1 および PP2A をそれぞれ 0.3 および 0.3 nM の IC50 で阻害することにより、その細胞毒性を発揮します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 96180-79-9
Sample solution is provided at 25 µL, 10mM.
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Microcystins are hepatotoxic cyclic heptapeptide toxins produced by cyanobacteria. They are responsible for periodic poisonings of humans and livestock following consumption of freshwater in areas where the blue-green algae are endemic. The toxicity of microcystins is initiated by the inhibition of the catalytic activity of protein phosphatase (PP) 1 and PP2A. Microcystin-LA differs from the major microcystin variant LR with the substitution of alanine in place of the arginine. It inhibits both PP1C and PP2A with an IC50 value of 0.3 nM.
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