ML115 (Synonyms: CID 6619100, SID 14735210) |
| カタログ番号GC44213 |
シグナルトランスデューサーおよびアクティベーター3（STAT3）は、炎症とがんに関する役割を持つサイトカイン誘導性の転写因子です。
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Cas No.: 912798-42-6
Sample solution is provided at 25 µL, 10mM.
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Signal transducer and activator of transcription 3 (STAT3) is a cytokine-inducible transcription factor with roles in inflammation and cancer. ML115 is an isoxazole carboxamide that acts as a cell-permeable STAT3 activator (EC50 = 2 nM) and is more than 28,000-fold selective for STAT3 over STAT1 and NF-κB. It shows no cytotoxicity against HT-1080 or NIH-3T3 cells. ML115 increases the expression of BCL3, a known STAT3-dependent oncogene, and enhances STAT3 activation by the pro-inflammatory cytokine IL-6. As the maintenance of pluripotency in mouse embryonic stem cells requires continued activation of STAT3, ML115 may be useful in maintaining embryonic stem cells in an undifferentiated state.
Average Rating: 5 (Based on Reviews and 15 reference(s) in Google Scholar.)
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