Mycophenolic Acid β-D-Glucuronide (Synonyms: MPAG，Mycophenolic Acid Glucosiduronate) |
| カタログ番号GC41325 |
ミコフェノール酸 β-D-グルクロニドは、免疫抑制剤ミコフェノール酸 (MPA) の代謝産物です。ミコフェノール酸 β-D-グルクロニドは抗腫瘍活性を示し、腺癌研究に使用できます。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 31528-44-6
Sample solution is provided at 25 µL, 10mM.
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Mycophenolic acid β-D-glucuronide (MPAG) is the primary metabolite of the antibiotic mycophenolic acid, a potent inhibitor of inosine monophosphate dehydrogenase. Inhibition of this enzyme blocks de novo GTP generation as well as RNA and DNA synthesis in lymphocytes, thus preventing lymphocyte proliferation and activation. Mycophenolic acid, typically used in clinical settings as a chemotherapeutic or immunosuppressant agent, is rapidly conjugated on adsorption and circulates mostly in the form of its glucuronide conjugate. At 6 mg/mouse/day, MPAG has been reported to show significant antitumor activity against Ehrlich solid tumors. This glucuronide is typically used as an internal standard for therapeutic drug monitoring analyses of serum or whole blood by HPLC or LC-MS to confirm that patients remain within the drug’s therapeutic range.
| Cas No. | 31528-44-6 | SDF | |
| 同義語 | MPAG，Mycophenolic Acid Glucosiduronate | ||
| Chemical Name | 5-[(2E)-5-carboxy-3-methyl-2-penten-1-yl]-1,3-dihydro-6-methoxy-7-methyl-3-oxo-4-isobenzofuranyl β-D-glucopyranosiduronic acid | ||
| Canonical SMILES | O=C1OCC2=C(C)C(OC)=C(C/C=C(C)/CCC(O)=O)C(O[C@@H]3O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]3O)=C21 | ||
| Formula | C23H28O12 | M.Wt | 496.5 |
| 溶解度 | 10mg/mL in DMSO; 5mg/mL in DMF | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.0141 mL | 10.0705 mL | 20.141 mL |
| 5 mM | 402.8 μL | 2.0141 mL | 4.0282 mL |
| 10 mM | 201.4 μL | 1.007 mL | 2.0141 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
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