N-Desmethyltamoxifen hydrochloride |
| カタログ番号GC38931 |
N-デスメチルタモキシフェン塩酸塩は、ヒトにおけるタモキシフェンの主要な代謝産物です。貧弱な抗エストロゲン剤である N-デスメチルタモキシフェンは、タモキシフェンよりも 10 倍強力なプロテインキナーゼ C (PKC) 阻害剤です。 N-デスメチルタモキシフェン塩酸塩は、ヒト AML 細胞におけるセラミド代謝の強力な調節因子でもあり、セラミドのグリコシル化、加水分解、およびスフィンゴシンのリン酸化を制限します。
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 15917-65-4
Sample solution is provided at 25 µL, 10mM.
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N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation[1][2][3].
N-desmethyltamoxifen hydrochloride (20-500 ng/ml; 48 hours) has a profound inhibitory effect upon all seven glioma lines (T98G, U87, U138, U373, ALW, AUK, CAS cells)[1].N-desmethyltamoxifen hydrochloride (1.5-10 μM; 114 hours) inhibits growth of MCF 7 human mammary carcinoma cells[2].N-desmethyltamoxifen hydrochloride, resulting from the CYP3A4/5-mediated catalysis of tamoxifen, is the major primary quantitative metabolite of tamoxifen[3]. Cell Viability Assay[2] Cell Line: MCF 7 human mammary carcinoma cells
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